The project explores the ligand-selective conformational dynamics of serotonin1A and the role of cholesterol in its regulation using GPU-enabled high-performance computing, Markov state Modelling and free energy simulations.
Principal Investigator: Dr. Sandipan Chakraborty, Associate Principal Research Scientist, Center for Innovation in Molecular and Pharmaceutical Sciences (CIMPS), Dr. Reddy’s Institute of Life Sciences, Hyderabad
Co-Principal Investigator: Prof. Amitabha Chattopadhyay, CSIR Bhatnagar Fellow, Membrane and GPCR Biophysics and Biology Group, Centre for Cellular and Molecular Biology, Hyderabad
